MR imaging quality and feasibility of a novel interleaved iTBS/fMRI setup

Abstract Introduction: Concurrent TMS/fMRI has become a promising technique for investigating the acute effects of rTMS on brain. However, image quality in concurrent may still have its limitations. In this study, we aimed to explore data before concluding findings from state-of-the-art setup ensure imaging was sufficient analysis. Methods: Nineteen healthy participants participated study. first session, performed baseline MRI scans with 64-channel head coil 3T Magnetom Prisma scanner and measured individual resting-motor thresholds (rMT). From second fourth ultrathin 14-channel MR receive coils standard iTBS protocol randomized three conditions each participant: 80% or 40% rMT over left DLPFC M1 region. these sessions, structural (MP2RAGE sequence) functional were acquired, resting-state fMRI (rsfMRI) immediately after stimulation, interleaved iTBS/fMRI. All rsfMRI preprocessed bias field correction, despiking, segmentation, coregistration, normalization, smoothing. Results: The mean TMS framewise displacement (FD) original target showed no significant difference between conditions. subjects condition had more than 3mm (Figure 1) related intolerance. MP2RAGE sequence provides satisfactory quality, but SNR CNR are inferior T1w 2). For imaging, compared both iTBS/fMRI; all improved significantly preprocessing 3). Discussions: This result demonstrates that novel high-quality scans. Additionally, an acceptable FD range confirmed further study supported by Federal Ministry Education Research: ERA-NET NEURON,FKZ:01EW1903View Large Image Figure ViewerDownload Hi-res Download (PPT)View (PPT) Research Category Technology Methods Translational 10. Transcranial Magnetic Stimulation (TMS) Keywords: TMS, fMRI,